|
Symbol Name ID |
Dnm2
dynamin 2 MGI:109547 |
| Darker colors indicate more annotations |
| Human Phenotypes | Facial palsy |
Easy fatigability |
Decreased number of peripheral myelinated nerve fibers |
Onion bulb formation |
Segmental peripheral demyelination |
Segmental peripheral demyelination/remyelination |
Peripheral axonal degeneration |
Axonal degeneration |
Areflexia |
Hyporeflexia |
Muscle fibrillation |
Motor delay |
Distal sensory impairment |
| Disease(s) Associated with DNM2 | |||||||||||||
| centronuclear myopathy 1 | |||||||||||||
| Charcot-Marie-Tooth disease dominant intermediate B |
| Mouse Phenotypes | hydrocephaly |
increased myelin sheath thickness |
abnormal neuromuscular synapse morphology |
small superior vagus ganglion |
encephalomeningocele |
demyelination |
abnormal action potential |
decreased nerve conduction velocity |
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| Availability | Mouse Genotype | ||||||||
| Dnm2b2b2159Clo/Dnm2b2b2159Clo | |||||||||
| Dnm2tm1.1(KOMP)Vlcg/Dnm2+ | |||||||||
| Dnm2tm2.1Ics/Dnm2+ | |||||||||
| Dnm2tm1Ueli/Dnm2tm2.1Ics Tg(Mpz-cre)26Mes/0 (conditional) |
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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